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Article

The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer.

Chemical communications (Cambridge, England) - 21 Dec 2010

Stojković Vanja, Perissinotti Laura L, Lee Jeeyeon, Benkovic Stephen J, Kohen Amnon

Abstract excerpt

Comparison of the nature of hydride transfer in wild-type and active site mutant (I14A) of dihydrofolate reductase suggests that the size of this side chain at position 14 modulates H-tunneling.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20972508
DOI: 10.1039/c0cc02988b
PMCID: PMC4346287

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20972508-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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