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Article

Prediction of homologous protein structures based on conformational searches and energetics.

Proteins - 1 Jan 1990

Schiffer C A, Caldwell J W, Kollman P A, Stroud R M

Abstract excerpt

A "knowledge-based" method of predicting the unknown structure of a protein from a homologous known structure using energetics to determine a sidechain conformation is proposed. The method consists of exchanging the residues in the known structure for the sequence of the unknown protein. Then a conformational search with molecular mechanics energy minimization is done on the exchanged residues. The lowest energy...

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PMID: 2217162
DOI: 10.1002/prot.340080107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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