Prediction of homologous protein structures based on conformational searches and energetics.

doi:10.1002/prot.340080107

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Article

Prediction of homologous protein structures based on conformational searches and energetics.

Proteins - 1 Jan 1990

Schiffer C A, Caldwell J W, Kollman P A, Stroud R M

Abstract excerpt

A "knowledge-based" method of predicting the unknown structure of a protein from a homologous known structure using energetics to determine a sidechain conformation is proposed. The method consists of exchanging the residues in the known structure for the sequence of the unknown protein. Then a c...

Topics

Animals
Artificial Intelligence
Cattle
Mutation
Protein Conformation
Rats
Sequence Homology, Nucleic Acid
Solvents
Thermodynamics
Trypsin
X-Ray Diffraction

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