Article
Predicted three-dimensional structure of the protease inhibitor domain of the Alzheimer's disease beta-amyloid precursor.
Proteins - 1 Jan 1991
Struthers R S, Kitson D H, Hagler A T
Abstract excerpt
Alzheimer's disease is characterized by the deposition of amyloid beta-protein as plaques and tangles in the brains of its victims. The amyloid precursor can be expressed with or without the inclusion of a protease inhibitor domain, the potential role of which in amyloidogenesis has prompted the generation of a model of its three-dimensional structure based on the known structure of a related inhibitor. The model...
Topics
- Amino Acid Sequence
- Amyloid beta-Peptides
- Binding Sites
- Drug Design
- Electronic Data Processing
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Reproducibility of Results
- Stereoisomerism