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Article

Contact-based sequence alignment.

Nucleic acids research - 1 Jan 2004

Kleinjung Jens, Romein John, Lin Kuang, Heringa Jaap

Abstract excerpt

This paper introduces the novel method of contact-based protein sequence alignment, where structural information in the form of contact mutation probabilities is incorporated into an alignment routine using contact-mutation matrices (CAO: Contact Accepted mutatiOn). The contact-based alignment routine optimizes the score of matched contacts, which involves four (two per contact) instead of two residues per match...

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Identifiers

PMID: 15121903
DOI: 10.1093/nar/gkh566
PMCID: PMC419454

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PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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