Article
Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*.
Glia - 1 Dec 2011
Tarassishin Leonid, Loudig Olivier, Bauman Avital, Shafit-Zagardo Bridget, Suh Hyeon-Sook, Lee Sunhee C
Abstract excerpt
Astrocytes, together with microglia and macrophages, participate in innate inflammatory responses in the CNS. Although inflammatory mediators such as interferons generated by astrocytes may be critical in the defense of the CNS, sustained unopposed cytokine signaling could result in harmful consequences. Interferon regulatory factor 3 (IRF3) is a transcription factor required for IFNβ production and antiviral...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.