Variation in tissue outcome of ovine and human engineered heart valve constructs: relevance for tissue engineering.

doi:10.2217/rme.11.100

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Article

Variation in tissue outcome of ovine and human engineered heart valve constructs: relevance for tissue engineering.

Regenerative medicine - 1 Jan 2012

van Geemen Daphne, Driessen-Mol Anita, Grootzwagers Leonie G M, Soekhradj-Soechit R Sarita, Riem Vis Paul W, Baaijens Frank P T, Bouten Carlijn V C

Abstract excerpt

AIM: Clinical application of tissue engineered heart valves requires precise control of the tissue culture process to predict tissue composition and mechanical properties prior to implantation, and to understand the variation in tissue outcome. To this end we investigated cellular phenotype and tissue properties of ovine (n = 8) and human (n = 7) tissue engineered heart valve constructs to quantify variations in...

Topics

Animals
Biomechanical Phenomena
Cell Count
Extracellular Matrix
Female
Heart Valve Prosthesis
Humans
Male
Middle Aged
Myofibroblasts
Phenotype
Sheep, Domestic
Tissue Engineering

Source

Open in PubMed

Identifiers

PMID: 22168498
DOI: 10.2217/rme.11.100

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