Three-dimensional topography of synthetic scaffolds induces elastin synthesis by human coronary artery smooth muscle cells.

Abstract excerpt

Due to the important structural and signaling roles of elastin in vascular stability, engineered human vascular tissues must incorporate elastin. However, despite considerable progress toward engineering of elastin-containing vascular tissues from animal cells, currently engineered vascular tissues using human cells largely lack elastin. In this study, we evaluated the effect of scaffold topography (two...

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