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Article

Recellularization of a novel off-the-shelf valve following xenogenic implantation into the right ventricular outflow tract.

PloS one - 1 Jan 2017

Hennessy Ryan S, Go Jason L, Hennessy Rebecca R, Tefft Brandon J, Jana Soumen, Stoyles Nicholas J, Al-Hijji Mohammed A, Thaden Jeremy J, Pislaru Sorin V, Simari Robert D, Stulak John M, Young Melissa D, Lerman Amir

Abstract excerpt

Current research on valvular heart repair has focused on tissue-engineered heart valves (TEHV) because of its potential to grow similarly to native heart valves. Decellularized xenografts are a promising solution; however, host recellularization remains challenging. In this study, decellularized porcine aortic valves were implanted into the right ventricular outflow tract (RVOT) of sheep to investigate...

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Share to Aortic Valve
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28763463
DOI: 10.1371/journal.pone.0181614
PMCID: PMC5538661

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