Synthesis and characterization of oligodeoxynucleotides containing the mutagenic base analogue 4-O-ethylthymine.

doi:10.1093/nar/18.19.5729

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Article

Synthesis and characterization of oligodeoxynucleotides containing the mutagenic base analogue 4-O-ethylthymine.

Nucleic acids research - 11 Oct 1990

Fernandez-Forner D, Palom Y, Ikuta S, Pedroso E, Eritja R

Abstract excerpt

A method for the preparation of oligonucleotides containing the mutagenic base 4-O-ethylthymine is described for the first time. Use of p-nitrophenylethyl type base protecting groups together with phosphitetriester solid-phase methodology makes possible the rapid and efficient preparation of olig...

Topics

Base Sequence
Molecular Sequence Data
Molecular Structure
Mutation
Oligodeoxyribonucleotides
Thymine

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