Article
Genotoxicity of excess thymidylate in thymidylate low-requiring Saccharomyces cerevisiae is associated with changes in phosphate metabolism.
Mutation research - 1 Jan 2000
Holderried J, Liedtke H, Brendel M
Abstract excerpt
When dTMP in concentrations greater than 100 microM is offered to growing cells of thymidylate low-requiring yeast strains it is both mutagenic and toxic. At exposure concentrations greater than 1 mM dTMP interferes significantly with the low-affinity phosphate permease even in the presence of ex...
Topics
- Biological Transport
- Cell Survival
- Magnetic Resonance Spectroscopy
- Mutation
- Phosphates
- Saccharomyces cerevisiae
- Thymidine Monophosphate
- Thymine Nucleotides