Neighborhood properties are important determinants of temperature sensitive mutations.

Abstract excerpt

Temperature-sensitive (TS) mutants are powerful tools to study gene function in vivo. These mutants exhibit wild-type activity at permissive temperatures and reduced activity at restrictive temperatures. Although random mutagenesis can be used to generate TS mutants, the procedure is laborious and unfeasible in multicellular organisms. Further, the underlying molecular mechanisms of the TS phenotype are poorly...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amino Acids
• Share to Area Under Curve
• Share to Artificial Intelligence