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Article

Structure-based kernels for the prediction of catalytic residues and their involvement in human inherited disease.

Bioinformatics (Oxford, England) - 15 Aug 2010

Xin Fuxiao, Myers Steven, Li Yong Fuga, Cooper David N, Mooney Sean D, Radivojac Predrag

Abstract excerpt

MOTIVATION: Enzyme catalysis is involved in numerous biological processes and the disruption of enzymatic activity has been implicated in human disease. Despite this, various aspects of catalytic reactions are not completely understood, such as the mechanics of reaction chemistry and the geometry of catalytic residues within active sites. As a result, the computational prediction of catalytic residues has the...

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Identifiers

PMID: 20551136
DOI: 10.1093/bioinformatics/btq319
PMCID: PMC2916715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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