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Article

The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity.

PloS one - 1 Jan 2011

Wong Li Chin, Costa Alexandre, McLeod Ian, Sarkeshik Ali, Yates John, Kyin Saw, Perlman David, Schedl Paul

Abstract excerpt

The Orb CPEB protein regulates translation of localized mRNAs in Drosophila ovaries. While there are multiple hypo- and hyperphosphorylated Orb isoforms in wild type ovaries, most are missing in orb(F303), which has an amino acid substitution in a buried region of the second RRM domain. Using a proteomics approach we identified a candidate Orb kinase, Casein Kinase 2 (CK2). In addition to being associated with...

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Identifiers

PMID: 21949709
DOI: 10.1371/journal.pone.0024355
PMCID: PMC3176278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity.PMID 21949709Read ↗

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The Drosophila CPEB protein Orb2 has a novel expression pattern and is important for asymmetric cell division and nervous system function.Semantic proximity Read ↗

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Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation.Semantic proximity Read ↗

The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity.Semantic proximity Read ↗

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Two distinct domains of Bruno bind specifically to the oskar mRNA.Semantic proximity Read ↗

Orb prevents autophagy in the <i>Drosophila</i> germline through translational repression of <i>Atg12</i> mRNASemantic proximity Read ↗

CK2 inhibits TIMELESS nuclear export and modulates CLOCK transcriptional activity to regulate circadian rhythmsSemantic proximity Read ↗

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