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Article

Origin of the diversity in DNA recognition domains in phasevarion associated modA genes of pathogenic Neisseria and Haemophilus influenzae.

PloS one - 1 Jan 2012

Gawthorne Jayde A, Beatson Scott A, Srikhanta Yogitha N, Fox Kate L, Jennings Michael P

Abstract excerpt

Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic bacteria. In some it has been demonstrated that the random switching of the mod (DNA methyltransferase) gene mediates the coordinated expression of multiple genes and constitutes a phasevarion (phase variable regulon). ModA of Neisseria and Haemophilus influenzae contain a highly variable, DNA recognition domain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22457715
DOI: 10.1371/journal.pone.0032337
PMCID: PMC3311624

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