Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dominant optic atrophy: updates on the pathophysiology and clinical manifestations of the optic atrophy 1 mutation.

Current opinion in ophthalmology - 1 Nov 2016

Chun Bo Y, Rizzo Joseph F

Abstract excerpt

PURPOSE OF REVIEW: Review recent advances in clinical and experimental studies of dominant optic atrophy (DOA) to better understand the complexities of pathophysiology caused by the optic atrophy 1 (OPA1) mutation. RECENT FINDINGS: DOA is the most commonly diagnosed inherited optic atrophy, causing progressive bilateral visual loss that begins early in life. During the past 25 years, there has been substantial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to GTP Phosphohydrolases
Share to Homeostasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Optic Atrophy, Autosomal Dominant

Share to Oxidative Phosphorylation

Share to Reactive Oxygen Species

Share to Retinal Ganglion Cells

Source

Identifiers

PMID: 27585216
DOI: 10.1097/ICU.0000000000000314

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dominant optic atrophy: updates on the pathophysiology and clinical manifestations of the optic atrophy 1 mutation.PMID 27585216Read ↗

Dominant optic atrophySemantic proximity Read ↗

OPA1 Dominant Optic Atrophy: Pathogenesis and Therapeutic Targets.Semantic proximity Read ↗

Targeting the OPA1 pathway in Autosomal Dominant Optic Atrophy (ADOA): 25 years from gene discovery to therapeutic strategy.Semantic proximity Read ↗

OPA1: How much do we know to approach therapy?Semantic proximity Read ↗

Mitochondrial optic neuropathies: how two genomes may kill the same cell type?Semantic proximity Read ↗

Insights on the Genetic and Phenotypic Complexities of Optic Neuropathies.Semantic proximity Read ↗

A review of primary hereditary optic neuropathies.Semantic proximity Read ↗

[Not only optic neuropathy: new molecular and clinical aspects of OPA1 gene mutations].Semantic proximity Read ↗

Rhesus macaques with an OPA1 mutation demonstrate features of autosomal dominant optic atrophy.Semantic proximity Read ↗

A Review of Mitochondrial Optic Neuropathies: From Inherited to Acquired FormsSemantic proximity Read ↗

Biallelic Optic Atrophy 1 (OPA1) Related Disorder-Case Report and Literature Review.Semantic proximity Read ↗

Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.