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Article

Mitochondrial Ca2+ uptake correlates with the severity of the symptoms in autosomal dominant optic atrophy.

Cell calcium - 1 Jan 2015

Fülöp László, Rajki Anikó, Maka Erika, Molnár Mária Judit, Spät András

Abstract excerpt

The most frequent form of hereditary blindness, autosomal dominant optic atrophy (ADOA), is caused by the mutation of the mitochondrial protein Opa1 and the ensuing degeneration of retinal ganglion cells. Previously we found that knockdown of OPA1 enhanced mitochondrial Ca(2+) uptake (Fülöp et al., 2011). Therefore we studied mitochondrial Ca(2+) metabolism in fibroblasts obtained from members of an ADOA family....

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Source

Identifiers

PMID: 25533789
DOI: 10.1016/j.ceca.2014.11.008

Genes

OPA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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