Article
Multiplex ligation-dependent probe amplification equals fluorescence in-situ hybridization for the identification of patients at risk for metastatic disease in uveal melanoma.
Melanoma research - 1 Feb 2012
Vaarwater Jolanda, van den Bosch Thomas, Mensink Hanneke W, van Kempen Chantal, Verdijk Rob M, Naus Nicole C, Paridaens Dion, Brüggenwirth Hennie T, Kiliç Emine, de Klein Annelies
Abstract excerpt
In uveal melanoma, loss of chromosome 3 and gain of chromosome 8q are associated with a high risk of metastasis. In this study, we validated the use of multiplex ligation-dependent probe amplification (MLPA) in detecting patients at risk for metastatic disease in comparison with the predictive power of fluorescence in-situ hybridization (FISH). For 64 uveal melanoma samples, the MLPA results of chromosome 3 and 8...
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