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Article

A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

The Journal of biological chemistry - 21 Aug 2015

Mathiassen Søs G, Larsen Ida B, Poulsen Esben G, Madsen Christian T, Papaleo Elena, Lindorff-Larsen Kresten, Kragelund Birthe B, Nielsen Michael L, Kriegenburg Franziska, Hartmann-Petersen Rasmus

Abstract excerpt

A mutation, L166P, in the cytosolic protein, PARK7/DJ-1, causes protein misfolding and is linked to Parkinson disease. Here, we identify the fission yeast protein Sdj1 as the orthologue of DJ-1 and calculate by in silico saturation mutagenesis the effects of point mutants on its structural stability. We also map the degradation pathways for Sdj1-L169P, the fission yeast orthologue of the disease-causing DJ-1...

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Source

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Identifiers

PMID: 26152728
DOI: 10.1074/jbc.M115.662312
PMCID: PMC4543670

Genes

PARK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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