Article
Global stress response in a prokaryotic model of DJ-1-associated Parkinsonism.
Journal of bacteriology - 1 Mar 2013
Messaoudi Nadia, Gautier Valérie, Kthiri Fatoum, Lelandais Gaelle, Mihoub Mouadh, Joseleau-Petit Danièle, Caldas Teresa, Bohn Chantal, Tolosa Leah, Rao Govind, Tao Kazuyuki, Landoulsi Ahmed, Bouloc Philippe, Richarme Gilbert
Abstract excerpt
YajL is the most closely related Escherichia coli homolog of Parkinsonism-associated protein DJ-1, a protein with a yet-undefined function in the oxidative-stress response. YajL protects cells against oxidative-stress-induced protein aggregation and functions as a covalent chaperone for the thiol proteome, including FeS proteins. To clarify the cellular responses to YajL deficiency, transcriptional profiling of...
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