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Enhancement of Hepatitis B Virus Replication by Androgen and Its Receptor in Mice

8 Dec 2011

Abstract excerpt

Hepatitis B virus (HBV) is an important pathogen that chronically infects more men than women. To understand the molecular mechanism of this gender disparity, we analyzed HBV replication in transgenic mice that carried the HBV genome with or without the ability to express the HBV X protein (HBx). We found that gender had no effect on HBV surface antigen (HBsAg), DNA, and RNA levels in mice before puberty, but its...

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PMID: 22156518
DOI: 10.1128/jvi.06707-11

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