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Article

Male-specific hepatitis B virus large surface protein variant W4P potentiates tumorigenicity and induces gender disparity.

Molecular cancer - 3 Feb 2015

Lee Seoung-Ae, Kim Hong, Won You-Sub, Seok Seung-Hyeok, Na YiRang, Shin Han-Bo, Inn Kyung-Soo, Kim Bum-Joon

Abstract excerpt

BACKGROUND: The underlying mechanisms of carcinogenesis and gender disparity in hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) remain unclear. Recently, we reported a novel HCC-related W4P/R mutation in the large surface protein (LHB) of HBV genotype C, which was found exclusively in male HCC patients. METHODS: LHB sequences from a carrier (wild type; WT) and W4P variant LHB sequence from an HCC...

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Share to Tumor Burden
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25645622
DOI: 10.1186/s12943-015-0303-7
PMCID: PMC4326317

Genes

LHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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