Article
Hormonal regulation of hepatitis B virus gene expression: influence of androgen receptor.
Pediatric research - 1 Sept 1993
Breidbart S, Burk R D, Saenger P
Abstract excerpt
Adult HBV-transgenic males produce more hepatitis B surface antigen (HBsAg) in serum than females. The difference decreases with castration and is restored with testosterone replacement. To investigate the contribution of the androgen receptor in this process, HBV-transgenic males were mated with...
Topics
- Androgen-Insensitivity Syndrome
- Animals
- Dexamethasone
- Female
- Gene Expression Regulation, Viral
- Genotype
- Hepatitis B
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Male
- Mice
- Mice, Transgenic
- Orchiectomy
- Phenotype
- Receptors, Androgen
- Testosterone