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Article

Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance.

Hepatology (Baltimore, Md.) - 1 May 2011

di Iulio Julia, Ciuffi Angela, Fitzmaurice Karen, Kelleher Dermot, Rotger Margalida, Fellay Jacques, Martinez Raquel, Pulit Sara, Furrer Hansjakob, Günthard Huldrych F, Battegay Manuel, Bernasconi Enos, Schmid Patrick, Hirschel Bernard, Barnes Eleanor, Klenerman Paul, Telenti Amalio, Rauch Andri

Abstract excerpt

UNLABELLED: The identification of associations between interleukin-28B (IL-28B) variants and the spontaneous clearance of hepatitis C virus (HCV) raises the issues of causality and the net contribution of host genetics to the trait. To estimate more precisely the net effect of IL-28B genetic variation on HCV clearance, we optimized genotyping and compared the host contributions in multiple- and single-source...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21360716
DOI: 10.1002/hep.24263
PMCID: PMC3128709

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