Article
Hamartoma-like lesions in the mouse retina: an animal model of Pten hamartoma tumour syndrome.
Disease models & mechanisms - 21 May 2018
Tachibana Nobuhiko, Touahri Yacine, Dixit Rajiv, David Luke Ajay, Adnani Lata, Cantrup Robert, Aavani Tooka, Wong Rachel O, Logan Cairine, Kurek Kyle C, Schuurmans Carol
Abstract excerpt
PTEN hamartoma tumour syndrome (PHTS) is a heterogeneous group of rare, autosomal dominant disorders associated with PTEN germline mutations. PHTS patients routinely develop hamartomas, which are benign tissue overgrowths comprised of disorganized 'normal' cells. Efforts to generate PHTS animal models have been largely unsuccessful due to the early lethality of homozygous germline mutations in Pten, together with...
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