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Article

Loss of conserved Gsdma3 self-regulation causes autophagy and cell death.

The Biochemical journal - 1 Jun 2015

Shi Peiliang, Tang An, Xian Li, Hou Siyuan, Zou Dayuan, Lv Yasu, Huang Zan, Wang Qinghua, Song Anying, Lin Zhaoyu, Gao Xiang

Abstract excerpt

Gasdermin A3 (Gsdma3) was originally identified in association with hair-loss phenotype in mouse mutants. Our previous study found that AE mutant mice, with a Y344H substitution at the C-terminal domain of Gsdma3, display inflammation-dependent alopecia and excoriation [Zhou et al. (2012) Am. J. Pathol. 180, 763-774]. Interestingly, we found that the newly-generated null mutant of Gsdma3 mice did not display the...

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Identifiers

PMID: 25825937
DOI: 10.1042/BJ20150204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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