Article

Epigenomic profiling of stem cells within the pilosebaceous unit identifies PRDM16 as a regulator of sebaceous gland homeostasis

2021-04-14

Abstract excerpt

The epidermis consists of different compartments such as the hair follicle (HF), sebaceous gland (SG) and interfollicular epidermis (IFE), each containing distinct stem cell (SC) populations. However, with the exception of the SCs residing within the HF bulge, other epidermal SC populations remain less well understood. Here we used an epigenomic strategy that combines H3K27me3 ChIP-seq and RNA-seq profiling to ide...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f54357df-f390-50f1-bf2d-40a8828c270e
DOI: 10.1101/2021.04.12.439446

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenomic profiling of stem cells within the pilosebaceous unit identifies PRDM16 as a regulator of sebaceous gland homeostasisDOI 10.1101/2021.04.12.439446Read

Development of an Integrated Single-Cell and Spatial Transcriptomics Atlas of Healthy Human Skin Focusing on the Pilosebaceous UnitSemantic proximity Read

Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling.Semantic proximity Read

Heterogeneity and plasticity of epidermal stem cellsSemantic proximity Read

The epidermal stem cell-supporting matricellular protein fibulin 7 modulates skin inflammatory response in a psoriasis modelSemantic proximity Read

Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesisSemantic proximity Read

Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the SkinSemantic proximity Read

JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skinSemantic proximity Read

Single-cell RNA sequencing of human epidermis identifies Lunatic fringe as a novel regulator of the stem cell compartmentSemantic proximity Read

Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile PhenotypeSemantic proximity Read

Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acneSemantic proximity Read

Epidermal basal domains organization highlights skin robustness to environmental exposureSemantic proximity Read

Skin single-cell transcriptomics reveals a core of sebaceous gland-relevant genes shared by mice and humansSemantic proximity Read