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Article

Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS.

Molecular immunology - 1 Jan 2012

Ermini Luca, Goodship Timothy H J, Strain Lisa, Weale Michael E, Sacks Steven H, Cordell Heather J, Fremeaux-Bacchi Veronique, Sheerin Neil S

Abstract excerpt

It is well established that common genetic variants in CFH, CD46 and the CFHRs are additional risk factors for the development of aHUS. To examine the hypothesis that common variants in other complement genes have a similar effect we genotyped 501 SNPs in 47 complement genes in 94 aHUS patients from Newcastle, 126 aHUS patients from Paris, 374 UK controls and 165 French controls. We replicated the associations in...

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Identifiers

PMID: 22153652
DOI: 10.1016/j.molimm.2011.11.003
PMCID: PMC3438446

Genes

CFH
CFHR2
CFHR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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