Article
Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.
Annals of human genetics - 1 Jan 2010
Sullivan Maren, Erlic Zoran, Hoffmann Michael M, Arbeiter Klaus, Patzer Ludwig, Budde Klemens, Hoppe Bernd, Zeier Martin, Lhotta Karl, Rybicki Lisa A, Bock Andreas, Berisha Gani, Neumann Hartmut P H
Abstract excerpt
Atypical hemolytic uremic syndrome (aHUS) is caused by several susceptibility genes. A registry including analyses of susceptibility genes, familial occurrence and genotype-phenotype correlation should provide classification insights. Registry data of 187 unrelated index patients included age at onset, gender, family history, relapse of aHUS and potentially triggering conditions. Mutation analyses were performed...
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