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Article

Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS

1 May 2019

Abstract excerpt

Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and renal failure. It is caused by genetic or acquired defects of the complement alternative pathway. Factor H autoantibodies (anti-FHs) have been reported in 10% of aHUS patients and are associated with the deficiency of factor H-related 1 (FHR1). However, FHR1 deficiency is not enough...

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PMID: 31118930
DOI: 10.3389/fimmu.2019.00853

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