Article
Breast cancer prognosis in BRCA1 and BRCA2 mutation carriers: an International Prospective Breast Cancer Family Registry population-based cohort study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jan 2012
Goodwin Pamela J, Phillips Kelly-Anne, West Dee W, Ennis Marguerite, Hopper John L, John Esther M, O'Malley Frances P, Milne Roger L, Andrulis Irene L, Friedlander Michael L, Southey Melissa C, Apicella Carmel, Giles Graham G, Longacre Teri A
Abstract excerpt
PURPOSE: To compare breast cancer prognosis in BRCA1 and BRCA2 mutation carriers with that in patients with sporadic disease. PATIENTS AND METHODS: An international population-based cohort study was conducted in Canada, the United States, and Australia of 3,220 women with incident breast cancer diagnosed between 1995 and 2000 and observed prospectively. Ninety-three had BRCA1 mutations; 71, BRCA2 mutations; one,...
Topics
- Adult
- Aged
- Australia
- Breast Neoplasms
- Canada
- Female
- Genes, BRCA1
- Genes, BRCA2
- Genetic Predisposition to Disease