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Article

Retinoid Signaling in Pancreatic Cancer, Injury and Regeneration

29 Dec 2011

Abstract excerpt

BACKGROUND: Activation of embryonic signaling pathways quiescent in the adult pancreas is a feature of pancreatic cancer (PC). These discoveries have led to the development of novel inhibitors of pathways such as Notch and Hedgehog signaling that are currently in early phase clinical trials in the treatment of several cancer types. Retinoid signaling is also essential for pancreatic development, and retinoid...

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PMID: 22220202
DOI: 10.1371/journal.pone.0029075

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