Article
Migraine in monogenic disorders: Shedding light on new therapeutic targets.
Cephalalgia : an international journal of headache - 1 Oct 2025
Mascarella Davide, Zhuang Zixuan Alice, Gliga Otilia, Santis Federico De, Rosignoli Chiara, Daputke Austeja, Njohjam Mundih Noelar, Mazzotta Elena, Adewinle Funmilola Eunice, Caronna Edoardo, Pozo-Rosich Patricia
Abstract excerpt
BackgroundMigraine is a common neurological disorder with a strong genetic component, yet the precise mechanisms underlying its genetic susceptibility remain largely unknown. Genome-wide association studies (GWAS) have identified multiple risk loci, but monogenic forms of migraine, particularly Familial Hemiplegic Migraine (FHM), have provided deeper insights into the pathophysiology of migraine. Studying...
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