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Article

Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities.

Protein science : a publication of the Protein Society - 1 Jan 2005

Hanaoka Shingo, Nagadoi Aritaka, Nishimura Yoshifumi

Abstract excerpt

Mammalian telomeres consist of long tandem arrays of double-stranded telomeric TTAGGG repeats packaged by the telomeric DNA-binding proteins TRF1 and TRF2. Both contain a similar C-terminal Myb domain that mediates sequence-specific binding to telomeric DNA. In a DNA complex of TRF1, only the single Myb-like domain consisting of three helices can bind specifically to double-stranded telomeric DNA. TRF2 also binds...

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Identifiers

PMID: 15608118
DOI: 10.1110/ps.04983705
PMCID: PMC2253311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities.PMID 15608118Read ↗

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