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Dramatic replacement of histone variants during genome remodeling in nuclear-transferred embryos

1 Dec 2011

Abstract excerpt

The genome of differentiated somatic nuclei is remodeled to a totipotent state when they are transplanted into enucleated oocytes. To clarify the mechanism of this genome remodeling, we analyzed changes in the composition of core histone variants in nuclear-transferred embryos, since recent evidence has revealed that chromatin structure can be remodeled as a result of variant histone replacement. We found that...

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PMID: 22139579
DOI: 10.4161/epi.6.12.18206

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