Article
Low metastatic potential of clone from murine colon adenocarcinoma 26 increased by transfection of activated c-erbB-2 gene.
Journal of the National Cancer Institute - 17 Oct 1990
Yusa K, Sugimoto Y, Yamori T, Yamamoto T, Toyoshima K, Tsuruo T
Abstract excerpt
We investigated the effect of an activated c-erbB-2 gene (also known as ERBB2) on metastatic potential. The c-erbB-2 gene was activated by mutation of the valine at position 659 within the transmembrane domain to glutamic acid. The activated c-erbB-2 expression vector was transfected into low-metastatic-potential NL-4 cells, which were established from a metastatic variant of murine colon adenocarcinoma 26. All...
Topics
- Adenocarcinoma
- Animals
- Blotting, Northern
- Blotting, Southern
- Colonic Neoplasms
- Gene Expression Regulation, Neoplastic
- Mice
- Mutation
- Neoplasm Metastasis
- Phenotype
- Transfection