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Article

Three novel beta3 domain-deletion peptides for the sensitive and specific detection of HPA-4 and six low frequency beta3-HPA antibodies.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2008

Stafford P, Garner S F, Huiskes E, Kaplan C, Kekomaki R, Santoso S, Tsuno N H, Watkins N A, Ouwehand W H

Abstract excerpt

BACKGROUND: Antibodies against human platelet antigens (HPA) are clinically important in fetal-maternal alloimmune thrombocytopenia, refractoriness to platelet transfusions and post-transfusion purpura. Of the 16 HPAs, nine are located on the beta3 subunit of the alphaIIb beta3 integrin. Antibody detection is generally based on platelet-derived alphaIIb beta3 from HPA-genotyped donors. Recombinant allelic beta3...

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Source

Identifiers

PMID: 18031296
DOI: 10.1111/j.1538-7836.2008.02843.x

Genes

ITGB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Three novel beta3 domain-deletion peptides for the sensitive and specific detection of HPA-4 and six low frequency beta3-HPA antibodies.PMID 18031296Read ↗

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