Article
A high occurrence of acquisition and/or expansion of C-CBL mutant clones in the progression of high-risk myelodysplastic syndrome to acute myeloid leukemia.
Neoplasia (New York, N.Y.) - 1 Nov 2011
Kao Hsiao-Wen, Sanada Masashi, Liang Der-Cherng, Lai Chang-Liang, Lee En-Hui, Kuo Ming-Chung, Lin Tung-Liang, Shih Yu-Shu, Wu Jin-Hou, Huang Chein-Fuang, Ogawa Seishi, Shih Lee-Yung
Abstract excerpt
The molecular pathogenesis of myelodysplastic syndrome (MDS) and its progression to secondary acute myeloid leukemia (sAML) remain to be explored. Somatic C-CBL mutations were recently described in MDS. Our study aimed to determine the role of C-CBL mutations in the progression of MDS to sAML and sought to correlate with clinicohematological features and outcome. Bone marrow samples from 51 patients with...
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