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Article

CBL mutation in chronic myelomonocytic leukemia secondary to familial platelet disorder with propensity to develop acute myeloid leukemia (FPD/AML).

Blood - 15 Mar 2012

Shiba Norio, Hasegawa Daisuke, Park Myoung-ja, Murata Chisato, Sato-Otsubo Aiko, Ogawa Chitose, Manabe Atsushi, Arakawa Hirokazu, Ogawa Seishi, Hayashi Yasuhide

Abstract excerpt

Familial platelet disorder with a propensity to develop acute myeloid leukemia (FPD/AML) is a rare autosomal dominant disease characterized by thrombocytopenia, abnormal platelet function, and a propensity to develop myelodysplastic syndrome (MDS) and AML. So far, > 20 affected families have been reported. Recently, a second RUNX1 alteration has been reported; however, no additional molecular abnormalities have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22138511
DOI: 10.1182/blood-2011-02-333435

Genes

CBL
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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