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Receptor Tyrosine Kinases and Targeted Cancer Therapeutics

1 Jan 2011

Abstract excerpt

The majority of growth factor receptors are composed of extracellular, transmembrane, and cytoplasmic tyrosine kinase (TK) domains. Receptor tyrosine kinase (RTK) activation regulates many key processes including cell growth and survival. However, dysregulation of RTK has been found in a wide range of cancers, and it has been shown to correlate with the development and progression of numerous cancers. Therefore,...

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PMID: 22130229
DOI: 10.1248/bpb.34.1774

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