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Article

Receptor tyrosine kinases as targets for anticancer drugs.

Trends in molecular medicine - 1 Jan 2002

Zwick Esther, Bange Johannes, Ullrich Axel

Abstract excerpt

Receptor tyrosine kinases (RTKs) are the primary mediators of the signaling network that transmit extracellular signals into the cell. Gene amplification and/or overexpression of RTK proteins or functional alterations caused by mutations in the corresponding genes or abnormal autocrine-paracrine growth factor loops contribute to constitutive RTK signaling, ultimately resulting in the manifestation of dysregulated...

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Share to Antibodies, Monoclonal
Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11796262
DOI: 10.1016/s1471-4914(01)02217-1

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