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Article

Intraprotomer masking of third variable loop (V3) epitopes by the first and second variable loops (V1V2) within the native HIV-1 envelope glycoprotein trimer.

Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2011

Liu Li, Cimbro Raffaello, Lusso Paolo, Berger Edward A

Abstract excerpt

Within the trimeric HIV-1 envelope (Env) spike, the first and second variable loops (V1V2 region) and the third variable loop (V3) of the gp120 subunit play dual roles in antibody recognition, because they contain neutralization epitopes and also participate in epitope masking. The spatial relationships between V1V2 and V3 and the associated mechanisms of epitope masking remain unclear. Here we investigated...

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Share to Antibodies, Monoclonal
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neutralization Tests

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Share to Protein Structure, Secondary

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Source

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Identifiers

PMID: 22128330
DOI: 10.1073/pnas.1104840108
PMCID: PMC3250183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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