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Article

Control of Human PIRH2 Protein Stability

1 Mar 2004

Abstract excerpt

Murine PIRH2 (mPIRH2) was recently identified as a RING finger-containing ubiquitin-protein isopeptide ligase that interacts with both p53 and the human androgen receptor. mpirh2 is a p53-responsive gene that is up-regulated by UV, and mPIRH2 protein has the capacity to polyubiquitylate p53, perhaps leading to p53 destruction. mpirh2 therefore has properties similar to those of the oncogene mdm2. Here, we have...

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PMID: 14701804
DOI: 10.1074/jbc.m312712200

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