Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells

9 Nov 2016

Abstract excerpt

is regulated by p53 itself thus forming a negative regulatory feedback loop. Functionally, by eliminating p53, Pirh2 facilitates tumorigenesis. However, the role of Pirh2 in cancer cells lacking p53 is yet not well understood. Therefore, we decided to elucidate the role of Pirh2 in p53-negative human non-small cell lung carcinoma cells, H1299. We found that ectopic expression of Pirh2 enhanced cell proliferation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to interferon and immune responses
Share to Peptidase Inhibition and Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28191284
DOI: 10.18632/genesandcancer.123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cellsPMID 28191284Read ↗

Expression of Pirh2, a Newly Identified Ubiquitin Protein Ligase, in Lung CancerSemantic proximity Read ↗

The Role of E3 Ligase Pirh2 in DiseaseSemantic proximity Read ↗

Role of Pirh2 in Mediating the Regulation of p53 and c-MycSemantic proximity Read ↗

Pirh2 RING‐finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapySemantic proximity Read ↗

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation.Semantic proximity Read ↗

Pirh2Semantic proximity Read ↗

Phosphorylation of Pirh2 by Calmodulin‐dependent kinase II impairs its ability to ubiquitinate p53Semantic proximity Read ↗

High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancersSemantic proximity Read ↗

The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation.Semantic proximity Read ↗

SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor-suppressive function in the development of hepatocellular carcinomaSemantic proximity Read ↗

RANBP9 and RANBP10 cooperate in regulating non-small cell lung cancer proliferationSemantic proximity Read ↗

c-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHITSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.