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Article

Reduced impact of pyrimethamine drug pressure on Plasmodium malariae dihydrofolate reductase gene.

Antimicrobial agents and chemotherapy - 1 Feb 2012

Khim Nimol, Kim Saorin, Bouchier Christiane, Tichit Magali, Ariey Frédéric, Fandeur Thierry, Chim Pheaktra, Ke Sopheakvatey, Sum Sarorn, Man Somnang, Ratsimbasoa Arsène, Durand Rémy, Ménard Didier

Abstract excerpt

Molecular investigations performed following the emergence of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum have allowed the identification of the dihydrofolate reductase (DHFR) enzyme as the target of pyrimethamine. Although clinical cases of Plasmodium malariae are not usually treated with antifolate therapy, incorrect diagnosis and the high frequency of undetected mixed infections has...

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Identifiers

PMID: 22123682
DOI: 10.1128/AAC.05284-11
PMCID: PMC3264216

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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