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Article

Base excision repair factors are promising prognostic and predictive markers in cancer.

Current molecular pharmacology - 1 Jan 2012

Gossage Lucy, Perry Christina, Abbotts Rachel, Madhusudan Srinivasan

Abstract excerpt

The cytotoxicity of both chemotherapy and radiotherapy is to a large extent directly related to their ability to induce DNA damage. The ability of cancer cells to recognise and repair this damage contributes to therapeutic resistance. Sub-optimal DNA repair in normal tissue may impair normal tissue tolerance. Inter-individual differences in DNA repair pathways may also influence the natural history and...

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Identifiers

PMID: 22122468
DOI: 10.2174/1874467211205010115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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