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Article

ABCB1-1Delta polymorphism can predict hematologic toxicity in dogs treated with vincristine.

Journal of veterinary internal medicine - 1 Jan 2000

Mealey K L, Fidel J, Gay J M, Impellizeri J A, Clifford C A, Bergman P J

Abstract excerpt

BACKGROUND: Dogs that harbor the naturally occurring ABCB1-1Delta polymorphism experience increased susceptibility to avermectin-induced neurological toxicosis as a result of deficient P-glycoprotein function. Whether or not the ABCB1-1Delta polymorphism affects susceptibility to toxicity of other P-glycoprotein substrate drugs has not been studied. HYPOTHESIS: Dogs that possess the ABCB1-1Delta mutation are more...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18537875
DOI: 10.1111/j.1939-1676.2008.0122.x

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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