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Article

Attenuation of mouse hepatitis virus by deletion of the LLRKxGxKG region of Nsp1.

PloS one - 1 Jan 2013

Lei Lin, Ying Sun, Baojun Luo, Yi Yang, Xiang He, Wenli Su, Zounan Sun, Deyin Guo, Qingyu Zhu, Jingmei Liu, Guohui Chang

Abstract excerpt

Coronaviruses are a family of large positive-sense RNA viruses that are responsible for a wide range of important veterinary and human diseases. Nsp1 has been shown to have an important role in the pathogenetic mechanisms of coronaviruses in vivo. To assess the function of a relatively conserved domain (LLRKxGxKG) of MHV nsp1, a mutant virus, MHV-nsp1-27D, with a 27 nts (LLRKxGxKG) deletion in nsp1, was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Murine hepatitis virus

Share to Promoter Regions, Genetic

Share to Protein Structure, Tertiary

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Share to Viral Nonstructural Proteins

Source

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Identifiers

PMID: 23593419
DOI: 10.1371/journal.pone.0061166
PMCID: PMC3620170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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