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Article

Repair and mutagenesis of the genome of a deletion mutant of the coronavirus mouse hepatitis virus by targeted RNA recombination.

Journal of virology - 1 Apr 1992

Koetzner C A, Parker M M, Ricard C S, Sturman L S, Masters P S

Abstract excerpt

The genetic characterization of a nucleocapsid (N) protein mutant of the coronavirus mouse hepatitis virus (MHV) is described. The mutant, Albany 4 (Alb4), is both temperature sensitive and thermolabile. Analysis of the progeny of a mixed infection showed that the defective Alb4 allele is recessive to wild type, and its gene product is diffusible. The N protein of Alb4 was found to be smaller than its wild-type...

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Identifiers

PMID: 1312608
DOI: 10.1128/JVI.66.4.1841-1848.1992
PMCID: PMC288970

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