Article
Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 2003
Fowkes Robert C, Desclozeaux Marion, Patel Mayur V, Aylwin Simon J B, King Peter, Ingraham Holly A, Burrin Jacky M
Abstract excerpt
In the anterior pituitary, expression of the common glycoprotein hormone alpha-subunit (alphaGSU) is mediated in part by multiple response elements residing in the distal promoter (-435 bp). One such site is the gonadotrope-specific element (GSE), which is bound by the orphan nuclear receptor ste...
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