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HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections

2 Oct 2017

Abstract excerpt

Transcriptional regulation of numerous interferon-regulated genes, including Toll-like receptor 3 (Tlr3), which encodes an innate immune sensor of viral double-stranded RNA, depends on the interferon regulatory factor 1 (IRF1) and IRF2 transcription factors. We detected specific abrogation of macrophage responses to polyinosinic-polycytidylic acid (poly(I:C)) resulting from three independent...

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PMID: 28970238
DOI: 10.1084/jem.20161630

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